Netsu Sokutei, 35 (4), p. 185, (2008)



Molecular Mobility of Glassy Pharmaceuticals

Although use of glassy state for pharmaceutical formulations is not a new idea, it is recognized again as a promising formulation technology to enhance dissolution rate due to increase in poorly soluble candidates. However, because of its low physical/chemical stability and difficulty in industrial manufacturing, number of commercialized formulations has still been limited. In this review, molecular mobility of glassy pharmaceuticals is introduced with great emphasis on its effect on the physical/chemical stability.